Mass flow model and essentiality of enzymes in metabolic networks
نویسندگان
چکیده
Abstract Understanding the metabolism mechanisms in living organisms is a major task for postgenomic biology. Cellular metabolism is usually represented by a complex network of reactants connected by chemical reactions catalyzed by enzymes. In this paper, a mass flow conservation model is proposed to describe the process of cellular metabolism, which can be formulated as a linear programming model. Based on such model, the importance of an enzyme is quantitatively defined in metabolic network according to the variation of mass flow and final products resulting from the deletion of the enzyme. This quantitative criterion can be used not only to predict the essentiality of enzyme but also to identify drug targets.
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